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4-Methyl-2-oxovaleric acid

Name: 4-Methyl-2-oxovaleric acid
Brand: Selleck Chemicals
SKU: S2987
Rating: 5 (1 reviews)

Synonyms: Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate

Catalog No.S2987 Purity:99.31%

4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) is released by Astrocytes to neurons and can be reaminated by aminotransferase to leucine. 4-Methyl-2-oxovaleric acid reduces the rate of protein degradation in skeletal muscle. 4-Methyl-2-oxovaleric acid acts as an uncoupler of oxidative phosphorylation (OXPHOS) and as a metabolic inhibitor possibly through its inhibitory effect on alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) activity.

4-Methyl-2-oxovaleric acid Chemical Structure

CAS No. 816-66-0

Purity & Quality Control

Batch: S298701 Purity: 99.31%

99.31

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Biological Activity

Description

Targets

OGDC ^[1]

OXPHOS ^[1]

References

Chemical Information & Solubility

Molecular Weight	130.14	Formula	C₆H₁₀O₃
CAS No.	816-66-0	SDF	--
Density	1.055 g/mL
Smiles	CC(C)CC(=O)C(O)=O
Storage (From the date of receipt)	2 years -20°C liquid	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	2 years -20°C liquid		1 month-20°Cin solvent

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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