Home Apoptosis TNF-alpha inhibitor - Interleukins inhibitor 3-Deazaadenosine hydrochloride For research use only.

3-Deazaadenosine hydrochloride

Synonyms: 3-DZA HCl, c3Ado HCl

3-Deazaadenosine HCl (3-DZA, c3Ado) is a potent inhibitor of S-adenosylhomocysteine hydrolase with Ki of 3.9 µM. 3-Deazaadenosine HCl inhibits bacterial lipopolysaccharide-induced transcription of TNF-α and IL-1β. 3-Deazaadenosine HCl inhibits the transcriptional activity of NF-κB, prevents FCS-induced Ras carboxyl methylation and reduces FCS-induced ERK1/2 and Akt phosphorylation. 3-Deazaadenosine HCl has anti-inflammatory, anti-proliferative and anti-HIV activities.

3-Deazaadenosine hydrochloride Chemical Structure

3-Deazaadenosine hydrochloride Chemical Structure

CAS No. 86583-19-9

Purity & Quality Control

3-Deazaadenosine hydrochloride Related Products

Signaling Pathway

TNF-alpha Signaling Pathways

TNF-alpha Signaling Pathway

Biological Activity

Description 3-Deazaadenosine HCl (3-DZA, c3Ado) is a potent inhibitor of S-adenosylhomocysteine hydrolase with Ki of 3.9 µM. 3-Deazaadenosine HCl inhibits bacterial lipopolysaccharide-induced transcription of TNF-α and IL-1β. 3-Deazaadenosine HCl inhibits the transcriptional activity of NF-κB, prevents FCS-induced Ras carboxyl methylation and reduces FCS-induced ERK1/2 and Akt phosphorylation. 3-Deazaadenosine HCl has anti-inflammatory, anti-proliferative and anti-HIV activities.
Targets
S-adenosylhomocysteine hydrolase [1]
(Cell-free assay)
3.9 μM(Ki)
In vitro
In vitro

3-Deazaadenosine HCl (3-DZA, c3Ado) is a potent inhibitor of S-adenosylhomocysteine hydrolase with Ki of 3.9 µM.

Chemical Information & Solubility

Molecular Weight 302.71 Formula

C11H15ClN4O4
CAS No. 86583-19-9 SDF --
Smiles C1=CN=C(C2=C1N(C=N2)C3C(C(C(O3)CO)O)O)N.Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 60 mg/mL ( (198.2 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 60 mg/mL

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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