Home Proteases Tyrosinase inhibitor 2-Ketoglutaric acid (alpha-ketoglutarate) For research use only.

2-Ketoglutaric acid (alpha-ketoglutarate)

Synonyms: alpha-ketoglutaric acid, 2-oxoglutaric acid

2-Ketoglutaric acid (alpha-ketoglutarate) is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase.

2-Ketoglutaric acid (alpha-ketoglutarate) Chemical Structure

2-Ketoglutaric acid (alpha-ketoglutarate) Chemical Structure

CAS No. 328-50-7

Purity & Quality Control

2-Ketoglutaric acid (alpha-ketoglutarate) Related Products

Biological Activity

Description 2-Ketoglutaric acid (alpha-ketoglutarate) is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05319262 Completed
Noise Exposure|Sleep Disturbance|Sleep Hygiene|Metabolic Disturbance|Cognitive Change
Göteborg University|University of Pennsylvania|University of Manitoba
 April 24 2022 Not Applicable
NCT04560309 Completed
Coronary Artery Bypass|Cardiopulmonary Bypass|Coronary Artery Disease
National Cardiovascular Center Harapan Kita Hospital Indonesia
 January 1 2021 Phase 3
NCT01880281 Completed
Acid Base Disorder
Michel Burnier|Centre Hospitalier Universitaire Vaudois
 June 2013 Not Applicable

Chemical Information & Solubility

Molecular Weight 146.10 Formula

C5H6O5
CAS No. 328-50-7 SDF --
Smiles C(CC(=O)O)C(=O)C(=O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 29 mg/mL ( (198.49 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 29 mg/mL

Ethanol : 29 mg/mL


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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