Home Proteases Tyrosinase inhibitor - Fungal chemical Kojic acid

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Kojic acid Tyrosinase inhibitor

Cat.No.S5174

Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.
Kojic acid Tyrosinase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 142.11

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Quality Control

Batch: S517401 DMSO]28 mg/mL]false]Water]25 mg/mL]false]]]false Purity: 99.99%
99.99

Chemical Information, Storage & Stability

Molecular Weight 142.11 Formula

C6H6O4

 Storage (From the date of receipt)
CAS No. 501-30-4 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C1=C(OC=C(C1=O)O)CO

Solubility

In vitro
Batch:

DMSO : 28 mg/mL ( (197.03 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 25 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
Tyrosinase [2]
0.28 mM
In vitro
Kojic acid (KA) acts as a good chelator of transition metal ions such as Cu2+ and Fe3+ and a scavenger of free radicals. This compound shows a competitive inhibitory effect on the monophenolase activity and a mixed inhibitory effect on the diphenolase activity of mushroom tyrosinase[1]. It could highly protect Chinese hamster ovary (CHO) cells against ionizing radiation with low toxicity[3].
In vivo
Kojic acid exerts its radioprotective effects on lethal or sub-lethal irradiation induced damages in mice[3].
References

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