Home Peptide Products Tirzepatide (LY3298176) sodium For research use only. Not for use in humans.

Tirzepatide (LY3298176) sodium

Tirzepatide (LY3298176, GIP/GLP-1 RA, TZP) sodium is a dual GIP/GLP-1 receptor agonist. Tirzepatide differentially induces internalization of the GIP and GLP-1 receptors with EC50 values of 18.2 nM and 18.1 nM, respectively.

Amino-acid Sequence

Tirzepatide (LY3298176) sodium Amino-acid Sequence

CAS No. 2023788-19-2 (free base)

Selleck's Tirzepatide (LY3298176) sodium has been cited by 5 publications

Purity & Quality Control

Batch: Purity: 99.96%
99.96

Chemical Information & Solubility

Storage (From the date of receipt) 3 years-20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (20.77 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Biological Activity

Description Tirzepatide (LY3298176, GIP/GLP-1 RA, TZP) sodium is a dual GIP/GLP-1 receptor agonist. Tirzepatide differentially induces internalization of the GIP and GLP-1 receptors with EC50 values of 18.2 nM and 18.1 nM, respectively.
Targets
GLP-1 receptor GIP receptor
18.1 nM 18.2 nM
In vitro
In vitro

In HEK293 cells, Tirzepatide induces internalization of the GIPR and has a propensity toward partial agonism, and this ultimately reflects in signaling bias toward the cAMP pathway versus β-arrestin recruitment.[1]
In Vivo
In vivo

LY3298176 shows glucose-dependent insulin secretion and improves glucose tolerance by acting on both GIP and GLP-1 receptors in mice. Chronic treatment with LY3298176 results in a significant dose-dependent decrease in body weight that is more pronounced than that observed with semaglutide.[2]

Product Information

Molecular Formula:

C225H348N48O68• XNa
Molecular Weight: 4813.45
CAS No.: 2023788-19-2 (free base)
Appearance: White Powder
Peptide Content (by %N): ≥80%
Single Impurity (by HPLC): ≤1.0%
Assay (By Anhydrous, Acetic Acid-free): 95.0~105.0%
MS: Consistent
Packing: plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage
(From the date of receipt):		 3 years-20°C powder
Shipping: Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)