Tirzepatide (LY3298176) sodium

Catalog No.P1206 Batch:P120601

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Technical Data

Formula

C225H348N48O68• XNa

Molecular Weight 4813.45 CAS No. 2023788-19-2 (free base)
Solubility (25°C)* In vitro DMSO 100 mg/mL (20.77 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Tirzepatide (LY3298176, GIP/GLP-1 RA, TZP) sodium is a dual GIP/GLP-1 receptor agonist. Tirzepatide differentially induces internalization of the GIP and GLP-1 receptors with EC50 values of 18.2 nM and 18.1 nM, respectively.
Targets
GLP-1 receptor [1] GIP receptor [1]
18.1 nM(EC50) 18.2 nM(EC50)
In vitro

In HEK293 cells, Tirzepatide induces internalization of the GIPR and has a propensity toward partial agonism, and this ultimately reflects in signaling bias toward the cAMP pathway versus β-arrestin recruitment.[1]

In vivo

LY3298176 shows glucose-dependent insulin secretion and improves glucose tolerance by acting on both GIP and GLP-1 receptors in mice. Chronic treatment with LY3298176 results in a significant dose-dependent decrease in body weight that is more pronounced than that observed with semaglutide.[2]

Density 95.0~105.0%

Protocol (from reference)

Selleck's Tirzepatide (LY3298176) sodium has been cited by 5 publications

Evidence that tirzepatide protects against diabetes-related cardiac damages [ Cardiovasc Diabetol, 2024, 23(1):112] PubMed: 38555463
Tirzepatide prevents neurodegeneration through multiple molecular pathways [ J Transl Med, 2024, 22(1):114] PubMed: 38287296
Tirzepatide attenuates mammary tumor progression in diet-induced obese mice [ bioRxiv, 2024, 2024.01.20.576484] PubMed: 38328151
Tirzepatide attenuates mammary tumor progression in diet-induced obese mice [ bioRxiv, 2024, 23:2024.01.20.576484.] PubMed: 38328151
Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety [ Mol Metab, 2023, 75:101775] PubMed: 37451343

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.