Home Peptide Products alpha-MSH TFA For research use only. Not for use in humans.

alpha-MSH TFA

alpha-MSH TFA (α-MSH TFA, α-MSH Trifluoroacetate, alpha-MSH Trifluoroacetate,α-Melanocyte-stimulating hormone TFA, α-Melanocyte-stimulating hormone Trifluoroacetate) is a 13-amino acid peptide hormone. an endogenous MC4R agonist. alpha-MSH TFA is an endogenous MC3R and MC4R agonist with EC50s of 0.16 nM and 56 nM for hMC3R and hMC4R in Hepa cells, respectively.

Amino-acid Sequence

alpha-MSH TFA Amino-acid Sequence

CAS No. 171869-93-5

Purity & Quality Control

Batch: P120701 DMSO] 100 mg/mL] false] Water] 50 mg/mL] false] Ethanol] Insoluble] false Purity: 99.76%
99.76

Chemical Information & Solubility

Storage (From the date of receipt) 3 years-20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (56.21 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 50 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Biological Activity

Description

alpha-MSH TFA (α-MSH TFA, α-MSH Trifluoroacetate, alpha-MSH Trifluoroacetate,α-Melanocyte-stimulating hormone TFA, α-Melanocyte-stimulating hormone Trifluoroacetate) is a 13-amino acid peptide hormone. an endogenous MC4R agonist. alpha-MSH TFA is an endogenous MC3R and MC4R agonist with EC50s of 0.16 nM and 56 nM for hMC3R and hMC4R in Hepa cells, respectively.
Targets
hMC3R hMC4
0.16 nM 56 nM
In vitro
In vitro

Alpha-MSH exerts an inhibitory effect on IL-8 production by macrophages, an influence that may occur via modulating NFκB activation. In human glioma cells, inflammatory reactions are modulated by α-MSH peptides, apparently by modulating NFκB activation through preventing IκB degradation.[2]
In Vivo
In vivo

Alpha-MSH inhibits both the induction and elicitation of contact sensitivity and can lead to hapten-specific tolerance. Although IL-10–deficient mice have reduced capacity to modulate both peripheral local and systemic inflammatory reactions, they are capable of reacting to exogenous α-MSH with reduced acute inflammatory reactions.[2]

Product Information

Molecular Formula:

C77H109N21O19S.xC2HF3O2
Molecular Weight: 1778.91
CAS No.: 171869-93-5
Appearance: White Powder
Peptide Content (by %N): ≥80%
Single Impurity (by HPLC): ≤1.0%
Assay (By Anhydrous, Acetic Acid-free): 95.0~105.0%
MS: Consistent
Packing: plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage
(From the date of receipt):		 3 years-20°C powder
Shipping: Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)