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Technical Data
| Formula | C77H109N21O19S.xC2HF3O2 |
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| Molecular Weight | 1778.91 | CAS No. | 171869-93-5 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (56.21 mM) | |
| Water | 50 mg/mL (28.1 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | alpha-MSH TFA (α-MSH TFA, α-MSH Trifluoroacetate, alpha-MSH Trifluoroacetate,α-Melanocyte-stimulating hormone TFA, α-Melanocyte-stimulating hormone Trifluoroacetate) is a 13-amino acid peptide hormone. an endogenous MC4R agonist. alpha-MSH TFA is an endogenous MC3R and MC4R agonist with EC50s of 0.16 nM and 56 nM for hMC3R and hMC4R in Hepa cells, respectively. |
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| Targets |
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| In vitro | Alpha-MSH exerts an inhibitory effect on IL-8 production by macrophages, an influence that may occur via modulating NFκB activation. In human glioma cells, inflammatory reactions are modulated by α-MSH peptides, apparently by modulating NFκB activation through preventing IκB degradation.[2] |
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| In vivo | Alpha-MSH inhibits both the induction and elicitation of contact sensitivity and can lead to hapten-specific tolerance. Although IL-10–deficient mice have reduced capacity to modulate both peripheral local and systemic inflammatory reactions, they are capable of reacting to exogenous α-MSH with reduced acute inflammatory reactions.[2] |
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| Density | 95.0~105.0% | |||||
Protocol (from reference)
References
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RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.