Cathepsin B

Cathepsin B Products

All (7)
Cathepsin B Inhibitors (6)
Cathepsin B Activator (1)
New Cathepsin B Products

Catalog No.	Product Name	Information	Product Use Citations
S1013	Bortezomib	Bortezomib is a potent 20S proteasome inhibitor with K_i of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.	Cell, 2024, 187(18):4905-4925.e24 Cell, 2024, S0092-8674(24)00315-5 Cell, 2024, S0092-8674(24)00653-6
S3012	Pazopanib	Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.	Cell Rep Med, 2024, S2666-3791(24)00201-5 Biomed Pharmacother, 2024, 180:117468 Transl Psychiatry, 2024, 14(1):166
S7380	Leupeptin Hemisulfate	Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.	Nat Commun, 2023, 14(1):4066 Acta Pharm Sin B, 2022, 12(6):2869-2886 Theranostics, 2022, 12(14):6395-6408
S7420	CA-074 methyl ester (CA-074 Me)	CA-074 methyl ester (CA-074 Me, Cathepsin B Inhibitor IV) is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.	Transl Psychiatry, 2024, 14(1):166 Reprod Biol, 2024, 24(1):100857 Res Sq, 2024, rs.3.rs-3979098
S7379	E-64	E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. E-64 induces oxidative stress and apoptosis in Filarial Parasite.	Cancer Cell, 2022, 40(9):1044-1059.e8 Molecules, 2022, 27(6)1755 Nat Nanotechnol, 2021, 10.1038/s41565-021-00988-z
S2847	Cathepsin Inhibitor 1	Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.	Elife, 2023, 12e79144 EMBO J, 2020, 39(1):e102030 Arterioscler Thromb Vasc Biol, 2020, ATVBAHA120315151
S4591	Nitroxoline	Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. Nitroxoline impairs tumor progression in vitro and in vivo by inhibiting cathepsin B activity.	Transl Psychiatry, 2024, 14(1):166 Int J Biol Sci, 2022, 18(13):5207-5220 Microorganisms, 2022, 10(7)1421
S1013	Bortezomib	Bortezomib is a potent 20S proteasome inhibitor with K_i of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.	Cell, 2024, 187(18):4905-4925.e24 Cell, 2024, S0092-8674(24)00315-5 Cell, 2024, S0092-8674(24)00653-6
S7380	Leupeptin Hemisulfate	Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.	Nat Commun, 2023, 14(1):4066 Acta Pharm Sin B, 2022, 12(6):2869-2886 Theranostics, 2022, 12(14):6395-6408
S7420	CA-074 methyl ester (CA-074 Me)	CA-074 methyl ester (CA-074 Me, Cathepsin B Inhibitor IV) is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.	Transl Psychiatry, 2024, 14(1):166 Reprod Biol, 2024, 24(1):100857 Res Sq, 2024, rs.3.rs-3979098
S7379	E-64	E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. E-64 induces oxidative stress and apoptosis in Filarial Parasite.	Cancer Cell, 2022, 40(9):1044-1059.e8 Molecules, 2022, 27(6)1755 Nat Nanotechnol, 2021, 10.1038/s41565-021-00988-z
S2847	Cathepsin Inhibitor 1	Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.	Elife, 2023, 12e79144 EMBO J, 2020, 39(1):e102030 Arterioscler Thromb Vasc Biol, 2020, ATVBAHA120315151
S4591	Nitroxoline	Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. Nitroxoline impairs tumor progression in vitro and in vivo by inhibiting cathepsin B activity.	Transl Psychiatry, 2024, 14(1):166 Int J Biol Sci, 2022, 18(13):5207-5220 Microorganisms, 2022, 10(7)1421
S3012	Pazopanib	Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.	Cell Rep Med, 2024, S2666-3791(24)00201-5 Biomed Pharmacother, 2024, 180:117468 Transl Psychiatry, 2024, 14(1):166

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