Adenosine Deaminase

Adenosine Deaminase Products

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Adenosine Deaminase Inhibitors (4)
Adenosine Deaminase Antagonist (1)
New Adenosine Deaminase Products

Catalog No.	Product Name	Information	Product Use Citations
S1199	Cladribine	Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.	Nat Commun, 2024, 15(1):9820 Oncotarget, 2024, 15:220-231 Exp Hematol Oncol, 2023, 12(1):23
S9521	Pentostatin	Pentostatin(CI-825,Deoxycoformycin) is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.	Res Sq, 2023, rs.3.rs-2276903 Nat Metab, 2020, 10.1038/s42255-020-0227-4
E1093	DNPH1i(N6-benzyladenosine)	N6-benzyladenosine (DNPH1i ) is an effective antiproliferative agent both in vitro and in vivo. It is a competitive inhibitor of DNPH1, limiting the activity of DNPH1 in vitro, and a competitive inhibitor of adenosine deaminase (ADA) in L-1210 cells.
S0950	Hibifolin	Hibifolin (Gossypetin-8-O-β-D-glucuronide) is a flavonol glycoside and acts as a potential inhibitor of adenosine deaminase (ADA) with a Ki of 49.92 μM. Hibifolin prevents β-amyloid-induced neurotoxicity in cultured cortical neurons.	Front Pharmacol, 2023, 14:1290868
E4031	8-Cyclopentyl-1,3-dimethylxanthine	8-Cyclopentyl-1,3-dimethylxanthine is a selective adenosine A1 receptor antagonist with Ki's of 10.9 nM and 1440 nM for A1 receptor and A2 receptor, respectively.
S1199	Cladribine	Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.	Nat Commun, 2024, 15(1):9820 Oncotarget, 2024, 15:220-231 Exp Hematol Oncol, 2023, 12(1):23
S9521	Pentostatin	Pentostatin(CI-825,Deoxycoformycin) is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.	Res Sq, 2023, rs.3.rs-2276903 Nat Metab, 2020, 10.1038/s42255-020-0227-4
E1093	DNPH1i(N6-benzyladenosine)	N6-benzyladenosine (DNPH1i ) is an effective antiproliferative agent both in vitro and in vivo. It is a competitive inhibitor of DNPH1, limiting the activity of DNPH1 in vitro, and a competitive inhibitor of adenosine deaminase (ADA) in L-1210 cells.
S0950	Hibifolin	Hibifolin (Gossypetin-8-O-β-D-glucuronide) is a flavonol glycoside and acts as a potential inhibitor of adenosine deaminase (ADA) with a Ki of 49.92 μM. Hibifolin prevents β-amyloid-induced neurotoxicity in cultured cortical neurons.	Front Pharmacol, 2023, 14:1290868
E4031	8-Cyclopentyl-1,3-dimethylxanthine	8-Cyclopentyl-1,3-dimethylxanthine is a selective adenosine A1 receptor antagonist with Ki's of 10.9 nM and 1440 nM for A1 receptor and A2 receptor, respectively.

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