CaSR

Catalog No.	Product Name	Information	Product Use Citations
S2633	NPS-2143	NPS-2143 (SB262470) is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM.	Biomed Pharmacother, 2023, 163:114843 Toxins (Basel), 2023, 16(1)21 Kaohsiung J Med Sci, 2022, 10.1002/kjm2.12601
S1260	Cinacalcet (AMG-073) HCl	Cinacalcet (Mimpara, Sensipar,AMG-073) HCl represents a new class of compounds for the treatment of hyperparathyroidism.	Int J Mol Sci, 2022, 23(8)4323 Int J Mol Sci, 2020, 21(20)E7617 Mol Cell Endocrinol, 2020, 501:110654
E0359	Evocalcet	Evocalcet (KHK7580) is an novel oral calcimimetic agent which acts via allosteric activation of the calcium sensing receptor (CaSR). Evocalcet (0, 20 and 60 nM) dose-dependently increases cytoplasmic [Ca2+] concentrations with an EC50 value of 92.7 nM in hCaR-HEK293 cells.
S1260	Cinacalcet (AMG-073) HCl	Cinacalcet (Mimpara, Sensipar,AMG-073) HCl represents a new class of compounds for the treatment of hyperparathyroidism.	Int J Mol Sci, 2022, 23(8)4323 Int J Mol Sci, 2020, 21(20)E7617 Mol Cell Endocrinol, 2020, 501:110654
E0359	Evocalcet	Evocalcet (KHK7580) is an novel oral calcimimetic agent which acts via allosteric activation of the calcium sensing receptor (CaSR). Evocalcet (0, 20 and 60 nM) dose-dependently increases cytoplasmic [Ca2+] concentrations with an EC50 value of 92.7 nM in hCaR-HEK293 cells.
S2633	NPS-2143	NPS-2143 (SB262470) is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM.	Biomed Pharmacother, 2023, 163:114843 Toxins (Basel), 2023, 16(1)21 Kaohsiung J Med Sci, 2022, 10.1002/kjm2.12601

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CaSRSignaling Pathway