Home GPCR & G Protein CaSR activator Evocalcet For research use only.

Evocalcet

Synonyms: KHK7580

Evocalcet (KHK7580) is an novel oral calcimimetic agent which acts via allosteric activation of the calcium sensing receptor (CaSR). Evocalcet (0, 20 and 60 nM) dose-dependently increases cytoplasmic [Ca2+] concentrations with an EC50 value of 92.7 nM in hCaR-HEK293 cells.

Evocalcet Chemical Structure

Evocalcet Chemical Structure

CAS No. 870964-67-3

Purity & Quality Control

Batch: E035901 DMSO]75 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.73%
99.73

Evocalcet Related Products

Signaling Pathway

CaSR Signaling Pathways

CaSR Signaling Pathway

Biological Activity

Description Evocalcet (KHK7580) is an novel oral calcimimetic agent which acts via allosteric activation of the calcium sensing receptor (CaSR). Evocalcet (0, 20 and 60 nM) dose-dependently increases cytoplasmic [Ca2+] concentrations with an EC50 value of 92.7 nM in hCaR-HEK293 cells.
Targets
CaSR [1]
92.7 nM(EC50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01935856 Completed
Hyperparathyroidism
Kyowa Kirin Co. Ltd.
 August 2013 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 374.48 Formula

C24H26N2O2
CAS No. 870964-67-3 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 75 mg/mL ( (200.27 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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