VDAC

VDAC Products

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VDAC Inhibitors (3)
VDAC Modulator (1)
New VDAC Products

Catalog No.	Product Name	Information	Product Use Citations
S7242	Erastin	Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Solutions are unstable and should be fresh-prepared.	Nat Commun, 2025, 16(1):509 EMBO J, 2025, 10.1038/s44318-025-00369-5 J Adv Res, 2025, S2090-1232(25)00075-X
S3544	VBIT-4	VBIT-4 is a voltage-dependent anion channel (VDAC) oligomerization inhibitor that decreases mitochondrial DNA (mtDNA) release, type I interferon (IFN) signaling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus.	Nature, 2023, 620(7973):374-380 Nature, 2023, 620(7973):374-380 Acta Pharm Sin B, 2023, 13(12):4765-4784
S8936	VBIT-12	VBIT-12 is a potent inhibitor of Voltage-dependent anion-selective channel 1 (VDAC1), directly interacting with purified VDAC1, reducing its channel conductance and preventing VDAC1 oligomerization.	PLoS Pathog, 2025, 21(1):e1012872 Heliyon, 2024, 10(1):e23426 Exp Cell Res, 2024, 434(2):113874
S0231	NSC15364	NSC 15364 (compound 59) is an inhibitor that directly interacts with VDAC1 and prevents VDAC1 oligomerization, concomitant with an inhibition of apoptosis.	Exp Cell Res, 2024, 434(2):113874
S3544	VBIT-4	VBIT-4 is a voltage-dependent anion channel (VDAC) oligomerization inhibitor that decreases mitochondrial DNA (mtDNA) release, type I interferon (IFN) signaling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus.	Nature, 2023, 620(7973):374-380 Nature, 2023, 620(7973):374-380 Acta Pharm Sin B, 2023, 13(12):4765-4784
S8936	VBIT-12	VBIT-12 is a potent inhibitor of Voltage-dependent anion-selective channel 1 (VDAC1), directly interacting with purified VDAC1, reducing its channel conductance and preventing VDAC1 oligomerization.	PLoS Pathog, 2025, 21(1):e1012872 Heliyon, 2024, 10(1):e23426 Exp Cell Res, 2024, 434(2):113874
S0231	NSC15364	NSC 15364 (compound 59) is an inhibitor that directly interacts with VDAC1 and prevents VDAC1 oligomerization, concomitant with an inhibition of apoptosis.	Exp Cell Res, 2024, 434(2):113874
S7242	Erastin	Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Solutions are unstable and should be fresh-prepared.	Nat Commun, 2025, 16(1):509 EMBO J, 2025, 10.1038/s44318-025-00369-5 J Adv Res, 2025, S2090-1232(25)00075-X

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