Home Apoptosis -DNA Damage/DNA Repair Thymidylate Synthase

Thymidylate Synthase

Thymidylate Synthase Products

  • All (10)
  • Thymidylate Synthase Inhibitors (10)
  • New Thymidylate Synthase Products
Catalog No. Product Name Information Product Use Citations Product Validations
S1209 5-FU (5-Fluorouracil) 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Mol Cancer, 2024, 23(1):186
Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887
Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0
S1135 Pemetrexed disodium Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Cell Death Dis, 2024, 15(8):555
Cell Commun Signal, 2024, 22(1):375
Cancer Cell, 2022, 40(10):1128-1144.e8
S5971 Pemetrexed Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887
Cell Rep Med, 2024, 5(7):101615
Mol Cancer Res, 2024, 22(1):82-93
S1192 Raltitrexed Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.
Mol Ther, 2022, S1525-0016(22)00717-1
ACS Chem Neurosci, 2022, 13(17):2646-2657
Biochem Biophys Res Commun, 2022, 610:1-7
S1778 Trifluridine (NSC 75520) Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.
Nat Med, 2023, 29(3):605-614
JCI Insight, 2022, 7(22e158060)
Biochem Biophys Res Commun, 2022, 610:119-126
S3731 Tipiracil hydrochloride Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.
Cell Mol Immunol, 2022, 10.1038/s41423-022-00842-9
JCI Insight, 2022, 7(22e158060)
S8539 TAS-102 TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.
STAR Protoc, 2024, 5(2):103090
J Exp Clin Cancer Res, 2023, 42(1):8
Adv Sci (Weinh), 2021, e2103360
S5790 Folinic acid (Leucovorin) Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.
Nat Commun, 2022, 13(1):6308
E4818New Pemetrexed (disodium heptahydrate) Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion.
S3169 2'-Deoxyuridine 5'-monophosphate disodium salt

2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.
S1209 5-FU (5-Fluorouracil) 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Mol Cancer, 2024, 23(1):186
Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887
Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0
S1135 Pemetrexed disodium Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Cell Death Dis, 2024, 15(8):555
Cell Commun Signal, 2024, 22(1):375
Cancer Cell, 2022, 40(10):1128-1144.e8
S5971 Pemetrexed Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887
Cell Rep Med, 2024, 5(7):101615
Mol Cancer Res, 2024, 22(1):82-93
S1192 Raltitrexed Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.
Mol Ther, 2022, S1525-0016(22)00717-1
ACS Chem Neurosci, 2022, 13(17):2646-2657
Biochem Biophys Res Commun, 2022, 610:1-7
S1778 Trifluridine (NSC 75520) Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.
Nat Med, 2023, 29(3):605-614
JCI Insight, 2022, 7(22e158060)
Biochem Biophys Res Commun, 2022, 610:119-126
S3731 Tipiracil hydrochloride Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.
Cell Mol Immunol, 2022, 10.1038/s41423-022-00842-9
JCI Insight, 2022, 7(22e158060)
S8539 TAS-102 TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.
STAR Protoc, 2024, 5(2):103090
J Exp Clin Cancer Res, 2023, 42(1):8
Adv Sci (Weinh), 2021, e2103360
S5790 Folinic acid (Leucovorin) Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.
Nat Commun, 2022, 13(1):6308
E4818New Pemetrexed (disodium heptahydrate) Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion.
S3169 2'-Deoxyuridine 5'-monophosphate disodium salt

2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.
E4818New Pemetrexed (disodium heptahydrate) Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion.

Choose Selective Thymidylate Synthase Inhibitors

Tags: Thymidylate Synthase inhibitor|Thymidylate Synthase agonist|Thymidylate Synthase activator|Thymidylate Synthase inducer|Thymidylate Synthase antagonist|Thymidylate Synthase signaling pathway|Thymidylate Synthase assay kit