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Thymidylate Synthase

Thymidylate Synthase Products

All (10)
Thymidylate Synthase Inhibitors (10)
New Thymidylate Synthase Products

Catalog No.	Product Name	Information	Product Use Citations
S1209	5-FU (5-Fluorouracil)	5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.	Nature, 2024, 635(8037):201-209 Mol Cancer, 2024, 23(1):186 Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887
S1135	Pemetrexed disodium	Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Cell Death Dis, 2024, 15(8):555 Cell Commun Signal, 2024, 22(1):375 Cancer Cell, 2022, 40(10):1128-1144.e8
S5971	Pemetrexed	Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Cell Rep Med, 2024, 5(7):101615 Mol Cancer Res, 2024, 22(1):82-93
S1192	Raltitrexed	Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.	Mol Ther, 2022, S1525-0016(22)00717-1 ACS Chem Neurosci, 2022, 13(17):2646-2657 Biochem Biophys Res Commun, 2022, 610:1-7
S1778	Trifluridine (NSC 75520)	Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.	Nat Med, 2023, 29(3):605-614 JCI Insight, 2022, 7(22e158060) Biochem Biophys Res Commun, 2022, 610:119-126
S3731	Tipiracil hydrochloride	Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.	Cell Mol Immunol, 2022, 10.1038/s41423-022-00842-9 JCI Insight, 2022, 7(22e158060)
S8539	TAS-102	TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.	STAR Protoc, 2024, 5(2):103090 J Exp Clin Cancer Res, 2023, 42(1):8 Adv Sci (Weinh), 2021, e2103360
S5790	Folinic acid (Leucovorin)	Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.	Nat Cell Biol, 2024, Nat Commun, 2022, 13(1):6308
E4818^New	Pemetrexed (disodium heptahydrate)	Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion.
S3169	2'-Deoxyuridine 5'-monophosphate disodium salt	2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.
S1209	5-FU (5-Fluorouracil)	5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.	Nature, 2024, 635(8037):201-209 Mol Cancer, 2024, 23(1):186 Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887
S1135	Pemetrexed disodium	Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Cell Death Dis, 2024, 15(8):555 Cell Commun Signal, 2024, 22(1):375 Cancer Cell, 2022, 40(10):1128-1144.e8
S5971	Pemetrexed	Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Cell Rep Med, 2024, 5(7):101615 Mol Cancer Res, 2024, 22(1):82-93
S1192	Raltitrexed	Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.	Mol Ther, 2022, S1525-0016(22)00717-1 ACS Chem Neurosci, 2022, 13(17):2646-2657 Biochem Biophys Res Commun, 2022, 610:1-7
S1778	Trifluridine (NSC 75520)	Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.	Nat Med, 2023, 29(3):605-614 JCI Insight, 2022, 7(22e158060) Biochem Biophys Res Commun, 2022, 610:119-126
S3731	Tipiracil hydrochloride	Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.	Cell Mol Immunol, 2022, 10.1038/s41423-022-00842-9 JCI Insight, 2022, 7(22e158060)
S8539	TAS-102	TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.	STAR Protoc, 2024, 5(2):103090 J Exp Clin Cancer Res, 2023, 42(1):8 Adv Sci (Weinh), 2021, e2103360
S5790	Folinic acid (Leucovorin)	Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.	Nat Cell Biol, 2024, Nat Commun, 2022, 13(1):6308
E4818^New	Pemetrexed (disodium heptahydrate)	Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion.
S3169	2'-Deoxyuridine 5'-monophosphate disodium salt	2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.
E4818^New	Pemetrexed (disodium heptahydrate)	Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion.

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