Thrombin

Thrombin Products

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Thrombin Inhibitors (6)
Thrombin Antibodie (1)
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Catalog No.	Product Name	Information	Product Use Citations
S2196	Dabigatran	Dabigatran is a potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM in a cell-free assay.	Int J Lab Hematol, 2024, 10.1111/ijlh.14300 J Clin Invest, 2023, 133(12)e165933 Thromb Res, 2023, 227:17-24
S1346	Heparin sodium	Heparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy.	Ecotoxicol Environ Saf, 2023, 252:114608 J Clin Transl Hepatol, 2023, 11(5):1079-1093 STAR Protoc, 2023, 4(1):102122
S2154	Dabigatran (BIBR-1048) etexilate	Dabigatran Etexilate (BIBR-1048) is the prodrug of dabigatran, a potent, nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule.	Sci Rep, 2022, 12(1):3955 Malar J, 2020, 15;19(1):155 Thromb Res, 2018, 170:97-101
S2069	Argatroban (MCI-9038)	Argatroban (MCI-9038) is a potent and selective synthetic thrombin inhibitor with K_i ranging from 5 nM to 39 nM, used as an anticoagulant.	Neural Regen Res, 2024, 19(2):434-439 Cancer Lett, 2023, 553:215983 J Neuroinflammation, 2022, 19(1):189
S5074	Argatroban Monohydrate	Argatroban (Argatroban hydrate, Argipidine,MCI-9038 Monohydrate) is a direct, selective thrombin inhibitor with anticoagulant effects.	Cancer Lett, 2023, 553:215983 Life Sci, 2021, 269:119073
S5960	Dabigatran etexilate mesylate	Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4.5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM.	bioRxiv, 2020, 10.1101/2020.04.22.054981
A2779	Befovacimab (Anti-TFPI)	Befovacimab (anti-TFPI) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitors (TFPI) with the potential to be used in haemophilia A/B research. MW: 143.24 kD.
S2196	Dabigatran	Dabigatran is a potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM in a cell-free assay.	Int J Lab Hematol, 2024, 10.1111/ijlh.14300 J Clin Invest, 2023, 133(12)e165933 Thromb Res, 2023, 227:17-24
S1346	Heparin sodium	Heparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy.	Ecotoxicol Environ Saf, 2023, 252:114608 J Clin Transl Hepatol, 2023, 11(5):1079-1093 STAR Protoc, 2023, 4(1):102122
S2154	Dabigatran (BIBR-1048) etexilate	Dabigatran Etexilate (BIBR-1048) is the prodrug of dabigatran, a potent, nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule.	Sci Rep, 2022, 12(1):3955 Malar J, 2020, 15;19(1):155 Thromb Res, 2018, 170:97-101
S2069	Argatroban (MCI-9038)	Argatroban (MCI-9038) is a potent and selective synthetic thrombin inhibitor with K_i ranging from 5 nM to 39 nM, used as an anticoagulant.	Neural Regen Res, 2024, 19(2):434-439 Cancer Lett, 2023, 553:215983 J Neuroinflammation, 2022, 19(1):189
S5074	Argatroban Monohydrate	Argatroban (Argatroban hydrate, Argipidine,MCI-9038 Monohydrate) is a direct, selective thrombin inhibitor with anticoagulant effects.	Cancer Lett, 2023, 553:215983 Life Sci, 2021, 269:119073
S5960	Dabigatran etexilate mesylate	Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4.5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM.	bioRxiv, 2020, 10.1101/2020.04.22.054981
A2779	Befovacimab (Anti-TFPI)	Befovacimab (anti-TFPI) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitors (TFPI) with the potential to be used in haemophilia A/B research. MW: 143.24 kD.

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