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Catalog No. Product Name Information Product Use Citations Product Validations
S7570 UNC0379 UNC0379 is a selective, substrate competitive inhibitor of N-lysine methyltransferase SETD8 with IC50 of 7.3 μM, high selectivity over 15 other methyltransferases.
Res Sq, 2024, rs.3.rs-4603170
Cell Death Dis, 2023, 10.1038/s41419-023-06167-3
Cell Death Dis, 2023, 14(9):638
S7983 A-196 A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over other histone methyltransferases and non-epigenetic targets.
iScience, 2023, 26(3):106158
Cancer Res, 2022, 82(8):1534-1547
Sci Total Environ, 2022, 838(Pt 1):155713
S7294 PFI-2 HCl PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
Biochem Biophys Res Commun, 2024, 708:149808
Life Sci Alliance, 2023, 6(5)e202201619
Pharmacol Res, 2022, 177:106122
S4635 Cyproheptadine hydrochloride sesquihydrate Cyproheptadine hydrochloride (Periactin, Peritol) is non-selective 5HT2 antagonist with IC50 of 0.6 nM. Also a SETD7/9 inhibitor.
Anticancer Res, 2019, 39(7):3767-3775
E1179 EZM0414 EZM0414 is a potent, selective, and orally bioavailable inhibitor of Histone-lysine N-methyltransferase SETD2.
S7570 UNC0379 UNC0379 is a selective, substrate competitive inhibitor of N-lysine methyltransferase SETD8 with IC50 of 7.3 μM, high selectivity over 15 other methyltransferases.
Res Sq, 2024, rs.3.rs-4603170
Cell Death Dis, 2023, 10.1038/s41419-023-06167-3
Cell Death Dis, 2023, 14(9):638
S7983 A-196 A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over other histone methyltransferases and non-epigenetic targets.
iScience, 2023, 26(3):106158
Cancer Res, 2022, 82(8):1534-1547
Sci Total Environ, 2022, 838(Pt 1):155713
S7294 PFI-2 HCl PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
Biochem Biophys Res Commun, 2024, 708:149808
Life Sci Alliance, 2023, 6(5)e202201619
Pharmacol Res, 2022, 177:106122
S4635 Cyproheptadine hydrochloride sesquihydrate Cyproheptadine hydrochloride (Periactin, Peritol) is non-selective 5HT2 antagonist with IC50 of 0.6 nM. Also a SETD7/9 inhibitor.
Anticancer Res, 2019, 39(7):3767-3775
E1179 EZM0414 EZM0414 is a potent, selective, and orally bioavailable inhibitor of Histone-lysine N-methyltransferase SETD2.

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Tags: SETD inhibitor | SETD activator | SETD inhibition