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Isoform-selective Products

RUNX Products

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  • RUNX Activators (4)
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Catalog No. Product Name Information Product Use Citations Product Validations
S9709 Muramyl dipeptide (MDP) Muramyl dipeptide (MDP) is a shared structural unit of peptidoglycans. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2.
Oxid Med Cell Longev, 2021, 2021:2353504
Front Cell Dev Biol, 2021, 9:707959
S3223 L-Quebrachitol L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.
S0790 CADD522 CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor-2)-DNA binding with IC50 of 10 nM. CADD522 exhibits anticancer activity.
E2909 L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate is a vitamin C derivative. L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.
S8756 XRK3F2 XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.
E2692 L-Ascorbic acid 2-phosphate sesquimagnesium salt L-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium), a long-acting vitamin C derivative that can stimulate collagen formation and expression, can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs), which increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.
S0790 CADD522 CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor-2)-DNA binding with IC50 of 10 nM. CADD522 exhibits anticancer activity.
S8756 XRK3F2 XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.
S9709 Muramyl dipeptide (MDP) Muramyl dipeptide (MDP) is a shared structural unit of peptidoglycans. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2.
Oxid Med Cell Longev, 2021, 2021:2353504
Front Cell Dev Biol, 2021, 9:707959
S3223 L-Quebrachitol L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.
E2909 L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate is a vitamin C derivative. L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.
E2692 L-Ascorbic acid 2-phosphate sesquimagnesium salt L-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium), a long-acting vitamin C derivative that can stimulate collagen formation and expression, can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs), which increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.

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Tags: RUNX inhibitor|RUNX agonist|RUNX activator|RUNX inducer|RUNX antagonist|RUNX signaling pathway|RUNX assay kit