Home Protein Tyrosine Kinase ROS1 inhibitor Zidesamtinib For research use only.

Zidesamtinib

Synonyms: NVL-520, NVL520

Zidesamtinib (NVL-520) is a potent brain-penetrating inhibitor of ROS1 tyrosine kinase with IC50 of 0.7 nM for wild-type ROS1 . It acts as a potential antineoplastic agent and can be used for the research of cancer.

Zidesamtinib Chemical Structure

Zidesamtinib Chemical Structure

CAS No. 2739829-00-4

Purity & Quality Control

Batch: E140901 DMSO]84 mg/mL]false]Ethanol]10 mg/mL]false]Water]Insoluble]false Purity: 99.06%
99.06

Zidesamtinib Related Products

Biological Activity

Description Zidesamtinib (NVL-520) is a potent brain-penetrating inhibitor of ROS1 tyrosine kinase with IC50 of 0.7 nM for wild-type ROS1 . It acts as a potential antineoplastic agent and can be used for the research of cancer.
Targets
ROS1 [1]
0.7 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05118789 Recruiting
Locally Advanced Solid Tumor|Metastatic Solid Tumor
Nuvalent Inc.
 January 4 2022 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 419.46 Formula

C22H22FN7O
CAS No. 2739829-00-4 SDF Download Zidesamtinib SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 84 mg/mL ( (200.25 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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