Home Epigenetics MLL inhibitor - Histone Methyltransferase inhibitor VTP50469 For research use only.

VTP50469

VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity.

VTP50469 Chemical Structure

VTP50469 Chemical Structure

CAS No. 2169916-18-9

Purity & Quality Control

Products often used together with VTP50469

SB590885

VTP50469 and SB590885 are used in the induction medium to generate hCiPSCs from hADSCs and hASFs.

Deng H, et al. 2022.

SGC-CBP30

VTP50469 and SGC-CBP30 are used in the induction medium to generate hCiPSCs from hADSCs and hASFs.

Deng H, et al. 2022.

JNK-IN-8

VTP50469 and JNK-IN-8 are used in the induction medium to generate hCiPSCs from hADSCs and hASFs.

Deng H, et al. 2022.

Doramapimod (BIRB 796)

VTP50469 and Doramapimod are used in the induction medium to generate hCiPSCs from hADSCs and hASFs.

Deng H, et al. 2022.

VTP50469 Related Products

Biological Activity

Description VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity.
Targets
Menin-MLL interaction [1]
(Cell-free assay)
104 pM(Ki)

Chemical Information & Solubility

Molecular Weight 630.82 Formula

C32H47FN6O4S
CAS No. 2169916-18-9 SDF --
Smiles CC(C)N(C(C)C)C(=O)C1=C(OC2=CN=CN=C2N3CC4(CCN(CC4)CC5CCC(CC5)N[S](C)(=O)=O)C3)C=CC(=C1)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (158.52 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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