Home Transmembrane Transporters Proton Pump inhibitor Vonoprazan Fumarate For research use only.

Vonoprazan Fumarate

Synonyms: TAK-438

Vonoprazan Fumarate(TAK-438), is a potent, orally active inhibitor of proton pump, specifically a potassium-competitive acid blocker (P-CAB), inhibiting H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. It exhibits potent antisecretory activity and can be used in research of acid-related disease.

Vonoprazan Fumarate Chemical Structure

Vonoprazan Fumarate Chemical Structure

CAS No. 881681-01-2

Purity & Quality Control

Batch: E498801 DMSO]92 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.65%
99.65

Vonoprazan Fumarate Related Products

Signaling Pathway

Proton Pump Signaling Pathways

Proton Pump Signaling Pathway

Biological Activity

Description Vonoprazan Fumarate(TAK-438), is a potent, orally active inhibitor of proton pump, specifically a potassium-competitive acid blocker (P-CAB), inhibiting H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. It exhibits potent antisecretory activity and can be used in research of acid-related disease.

Chemical Information & Solubility

Molecular Weight 461.47 Formula

C17H16FN3O2S.C4H4O4
CAS No. 881681-01-2 SDF Download Vonoprazan Fumarate SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 92 mg/mL ( (199.36 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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