Home Protein Tyrosine Kinase CSF-1R inhibitor - c-Kit inhibitor Vimseltinib For research use only.

Vimseltinib

Synonyms: DCC-3014

Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC50s of <0.01 μM and 0.1-1 μM, respectively.

Vimseltinib Chemical Structure

Vimseltinib Chemical Structure

CAS No. 1628606-05-2

Purity & Quality Control

Batch: E262901 DMSO]86 mg/mL]false]Ethanol]2 mg/mL]false]Water]Insoluble]false Purity: 99.09%
99.09

Vimseltinib Related Products

Signaling Pathway

CSF-1R Signaling Pathways

CSF-1R Signaling Pathway

Biological Activity

Description Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC50s of <0.01 μM and 0.1-1 μM, respectively.
Targets
c-Kit [1] CSF-1R [1]
0.1-1 μM <0.01 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03069469 Active not recruiting
Advanced Malignant Neoplasm|Pigmented Villonodular Synovitis|Giant Cell Tumor of Tendon Sheath|Tenosynovial Giant Cell Tumor|Tenosynovial Giant Cell Tumor Diffuse
Deciphera Pharmaceuticals LLC
 February 16 2017 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 431.49 Formula

C23H25N7O2
CAS No. 1628606-05-2 SDF --
Smiles CC(C)NC1=NC=C(C(=O)N1C)C2=CC=C(OC3=CC=NC(=C3)C4=C[N](C)N=C4)C(=N2)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 86 mg/mL ( (199.3 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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