Home Autophagy Mitophagy activator Urolithin A For research use only.

Urolithin A

Synonyms: 3,8-Dihydroxy Urolithin; 2',7-Dihydroxy-3,4-benzocoumarin

Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.

Urolithin A Chemical Structure

Urolithin A Chemical Structure

CAS No. 1143-70-0

Purity & Quality Control

Urolithin A Related Products

Biological Activity

Description Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.
In vitro
In vitro

Urolithin A inhibits cell proliferation and reduces oxidative stress status in liver cancer.
Cell Research Cell lines HepG2 cells
Concentrations 137 µM
Incubation Time 24 h
Method

Cells were treated with various concentrations of drug for 24 h.
Experimental Result Images Methods Biomarkers Images PMID
Western blot p53 / p21 / TIGAR p-cdc2 / Cyclin B1 / Cyclin D1 30418550
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06274749 Recruiting
Healthy Volunteer
National Institute on Aging (NIA)|National Institutes of Health Clinical Center (CC)
 May 15 2024 Not Applicable
NCT06362018 Recruiting
Healthy Adults
Amazentis SA|Mprex Healthcare Pvt. Ltd.
 May 7 2024 Not Applicable
NCT04783207 Completed
Healthy
Amazentis SA|Australian Catholic University
 April 21 2021 Not Applicable

Chemical Information & Solubility

Molecular Weight 228.20 Formula

C13H8O4
CAS No. 1143-70-0 SDF --
Smiles C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 46 mg/mL ( (201.57 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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