Ulocuplumab (Anti-CXCR4 / CD184)

Synonyms: BMS 936564; MDX 1338; Anti-Human CXCR4 Recombinant Antibody

Catalog No.A2523 Purity:99%

Ulocuplumab (Anti-CXCR4 / CD184) is a fully human IgG4 antibody, targeting CXCR4. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models. MW: 144.84 KD.

Purity & Quality Control

Batch: A252301 Purity: 99% Protein concentration: 6.72mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective CXCR Inhibitors

Name	Citation	CXCR1	CXCR2	CXCR4	CXCR3	Others
WZ811	20			++++
Mavorixafor	0			+
AMG 487	1				+++
Motixafortide (BL-8040)	0			++++		cyclin-D1,MCL-1,Bcl-2
Navarixin (SCH-527123)	4	++	+++
MSX-122	1			+++
LY2510924	2			++++
Reparixin (Repertaxin)	17	++++	+			CXCL8
SB225002	76		++
SB 265610		✔
Balixafortide (POL6326)			✔
SX-682	✔
MSX-130			✔
MSX-127			✔
AZD5069		✔
Danirixin (GSK1325756)		✔			CXCL8
LIT-927			✔		CXCL12
AMD3465 hexahydrobromide			✔

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Ulocuplumab (Anti-CXCR4 / CD184) is a fully human IgG4 antibody, targeting CXCR4. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models. MW: 144.84 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1375830-34-4
Molecular Weight	144.84 kDa
Isotype	Human IgG4SP
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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