Home Microbiology Reverse Transcriptase inhibitor Lersivirine (UK-453061) For research use only.

Lersivirine (UK-453061)

Lersivirine (UK-453061) is a potent and selective inhibitor of nonnucleoside reverse transcriptase (NNRTI) with IC50 of 0.119 μM.

Lersivirine (UK-453061) Chemical Structure

Lersivirine (UK-453061) Chemical Structure

CAS No. 473921-12-9

Purity & Quality Control

Lersivirine (UK-453061) Related Products

Signaling Pathway

Reverse Transcriptase Signaling Pathways

Reverse Transcriptase Signaling Pathway

Biological Activity

Description Lersivirine (UK-453061) is a potent and selective inhibitor of nonnucleoside reverse transcriptase (NNRTI) with IC50 of 0.119 μM.
Targets
NNRT [2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01220232 Completed
Healthy Volunteers
Pfizer|ViiV Healthcare
 November 2010 Phase 1
NCT01230385 Completed
Healthy Volunteers
Pfizer|ViiV Healthcare
 October 2010 Phase 1
NCT00925535 Completed
Healthy Volunteers
Pfizer
 May 2010 Phase 1
NCT01050751 Completed
Healthy Volunteers
Pfizer
 February 2010 Phase 1

Chemical Information & Solubility

Molecular Weight 310.35 Formula

C17H18N4O2
CAS No. 473921-12-9 SDF --
Smiles CCC1=C(C(=NN1CCO)CC)OC2=CC(=CC(=C2)C#N)C#N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 62 mg/mL ( (199.77 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 62 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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