Home Microbiology Antibiotics for Mammalian Cell Culture inhibitor - Antibiotics chemical Tylosin tartrate For research use only.

Tylosin tartrate

Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.

Tylosin tartrate Chemical Structure

Tylosin tartrate Chemical Structure

CAS No. 74610-55-2

Purity & Quality Control

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Biological Activity

Description Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.
In vitro
In vitro Tylosin tartrate (25 mg/L) significantly inhibits methane production relative to unamended controls, thus indicating that Tylosin tartrate at concentrations commonly found in swine lagoons can negatively impact anaerobic metabolism. [1] Tylosin disappearance follows a biphasic pattern, where rapid initial loss is followed by a slow removal phase. The 90% disappearance times for tylosin, relomycin (tylosin D), and desmycosin (tylosin B) in anaerobically incubated slurries are 30 to 130 hours, and aerating the slurries reduced the 90% disappearance times to between 12 and 26 hours. Tylosin tartrate is stable for at least one month when stored in Milli-Q water at pH 5.7 to 6.7 at 22 ℃. [2]
In Vivo
In vivo Tylosin increases splenocyte proliferation and splenocyte conditioned medium (CM) proliferative activity above control levels from whole splenocyte cultures in chickens. Tylosin also increases antitumor activity of splenocytes in chickens. [3] Tylosin tartrate (50 mg/kg) administered orally twice daily for 10 days, beginning 14 days after intranasal infection, significantly reduces the incidence and severity of macroscopical pneumonic lung lesions in neonatal piglets. [4] After tylosin tartrate administered intravenously (i.v.) at 10 mg/kg in camels, serum tylosin concentrations in the water-deprived camels are significantly higher, rate of drug elimination is slower, the volume of distribution is significantly smaller, and total body clearance is significantly slower than in the normal camels. On the other hand, serum tylosin concentrations are lower in the water deprived camels and the mean absorption time is significantly shorter in camels treat with tylosin tartrate (20 mg/kg i.m.). [5]

Chemical Information & Solubility

Molecular Weight 1066.19 Formula

C46H77NO17.C4H6O6
CAS No. 74610-55-2 SDF Download Tylosin tartrate SDF
Smiles CC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)C)COC4C(C(C(C(O4)C)O)OC)OC.C(C(C(=O)O)O)(C(=O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 300 mg/mL ( (281.37 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 300 mg/mL

Water : 200 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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