Home Angiogenesis HER2 inhibitor - Microtubule Associated inhibitor - Antibody-Drug Conjugate Trastuzumab-Emtansine（T-DM1） For research use only.

Trastuzumab-Emtansine（T-DM1）

Synonyms: Ado-Trastuzumab emtansine

Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.This product is supplied as 10mg/ml PBS solution. This product is discontinued. We recommend the replacement products: D4003

Trastuzumab-Emtansine（T-DM1） Chemical Structure

Trastuzumab-Emtansine（T-DM1） Chemical Structure

CAS No. 1018448-65-1 (ADC)

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Signaling Pathway

HER2 Signaling Pathways

HER2 Signaling Pathway

Biological Activity

Description Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.This product is supplied as 10mg/ml PBS solution. This product is discontinued. We recommend the replacement products: D4003
Targets
HER2 [1] Microtubule [1]
In vitro
In vitro

Trastuzumab emtansine significantly inhibits the proliferation of epithelial ovarian cancer (EOC) cells.
Cell Research Cell lines EOC cells
Concentrations 2 μg/ml
Incubation Time 24 h
Method

Cells were treated with various concentrations of drug for 24 h.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05945927 Recruiting
Breast Cancer
Hoffmann-La Roche
 September 13 2023 --
NCT05388149 Recruiting
Breast Cancer|HER2-positive Breast Cancer
University Health Network Toronto
 December 6 2022 Phase 2
NCT05754502 Recruiting
Breast Cancer
Consorzio Oncotech|Roche Pharma AG
 July 27 2021 --

Chemical Information & Solubility

Molecular Weight 145000 Formulation 10mg/mL in PBS
DAR 3.6 Antibody Trastuzumab
ADC Cytotoxin DM1 Formula N/A
CAS No. 1018448-65-1 (ADC) Storage (From the date of receipt) 1 year -80°C in solvent
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

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Frequently Asked Questions

Question 1:
What’s the solvent of this ADC drug? And what’s its concentration?

Answer:
The solvent is a PBS solution. The concentration is 10mg/ml.

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