Home Cytoskeletal Signaling Integrin antagonist Tirofiban For research use only.

Tirofiban

Synonyms: MK-383

Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.

Tirofiban Chemical Structure

Tirofiban Chemical Structure

CAS No. 144494-65-5

Purity & Quality Control

Batch: S308501 5%TFA]3.02 mg/mL]false]DMSO]0.005 mg/mL]false]Water]Insoluble]false Purity: 99.28%
99.28

Tirofiban Related Products

Signaling Pathway

Integrin Signaling Pathways

Integrin Signaling Pathway

Biological Activity

Description Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.
Targets
GPIIb/IIIa [1]
In vitro
In vitro

Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. [1][2] It inhibits platelet aggregation of gel-filtered platelets induced by 10 μM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ɑvβ3 vitronectin receptors, is 62 μmol/L. [2]
In Vivo
In vivo

Tirofiban (10 to 500 mg/kg or 360-min continuous i.v. infusions of 1 to 10 micrograms/kg/min) inhibits platelet aggregation responses to ADP and collagen in canine models. [3] When administered to humans at 0.15μg/kg/min for 4 h, Tirofiban produced a 2.5-fold increase in bleeding time and 97% inhibition of ADP-induced platelet aggregation. [4][5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05793671 Not yet recruiting
STEMI
Assiut University
 April 1 2023 Not Applicable
NCT03797729 Unknown status
ST Elevation Myocardial Infarction
Shanghai Zhongshan Hospital
 May 14 2019 Phase 4
NCT01766154 Completed
Renal Insufficiency
Medicure
 January 2013 Phase 1
NCT01336348 Completed
ST Segment Elevation Myocardial Infarction
Università degli Studi di Ferrara
 April 2010 Phase 3
NCT00407771 Unknown status
Coronary Artery Disease
Jordan Hospital|Merck Sharp & Dohme LLC
 November 2007 Phase 4
NCT00538317 Completed
Acute Myocardial Infarction
Hospices Civils de Lyon
 July 2007 Phase 4

Chemical Information & Solubility

Molecular Weight 440.6 Formula

C22H36N2O5S
CAS No. 144494-65-5 SDF Download Tirofiban SDF Download Tirofiban SDF
Smiles CCCCS(=O)(=O)NC(CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

5%TFA : 3.02 mg/mL

DMSO : 0.005 mg/mL ( (0.01 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Tirofiban | Tirofiban ic50 | Tirofiban price | Tirofiban cost | Tirofiban solubility dmso | Tirofiban purchase | Tirofiban manufacturer | Tirofiban research buy | Tirofiban order | Tirofiban mouse | Tirofiban chemical structure | Tirofiban mw | Tirofiban molecular weight | Tirofiban datasheet | Tirofiban supplier | Tirofiban in vitro | Tirofiban cell line | Tirofiban concentration | Tirofiban nmr