Home Cytoskeletal Signaling Integrin antagonist Tirofiban Hydrochloride For research use only.

Tirofiban Hydrochloride

Synonyms: MK-383 Hydrochloride

Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.

Tirofiban Hydrochloride Chemical Structure

Tirofiban Hydrochloride Chemical Structure

CAS No. 150915-40-5

Purity & Quality Control

Tirofiban Hydrochloride Related Products

Signaling Pathway

Integrin Signaling Pathways

Integrin Signaling Pathway

Biological Activity

Description Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.
Targets
GPIIb/IIIa [1]
In vitro
In vitro

Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. [1][2] It inhibits platelet aggregation of gel-filtered platelets induced by 10 μM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ɑvβ3 vitronectin receptors, is 62 μmol/L. [2]
In Vivo
In vivo

Tirofiban Hydrochloride (10 to 500 mg/kg or 360-min continuous i.v. infusions of 1 to 10 micrograms/kg/min) inhibits platelet aggregation responses to ADP and collagen in canine models. [3] When administered to humans at 0.15μg/kg/min for 4 h, Tirofiban produced a 2.5-fold increase in bleeding time and 97% inhibition of ADP-induced platelet aggregation. [4][5]
Animal Research Animal Models Adult mongrel dogs
Dosages ~500 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 495.07 Formula

C22H36N2O5S.HCl.H2O
CAS No. 150915-40-5 SDF Download Tirofiban Hydrochloride SDF
Smiles CCCCS(=O)(=O)NC(CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O.O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (201.99 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : ˂1 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Tirofiban Hydrochloride | Tirofiban Hydrochloride ic50 | Tirofiban Hydrochloride price | Tirofiban Hydrochloride cost | Tirofiban Hydrochloride solubility dmso | Tirofiban Hydrochloride purchase | Tirofiban Hydrochloride manufacturer | Tirofiban Hydrochloride research buy | Tirofiban Hydrochloride order | Tirofiban Hydrochloride mouse | Tirofiban Hydrochloride chemical structure | Tirofiban Hydrochloride mw | Tirofiban Hydrochloride molecular weight | Tirofiban Hydrochloride datasheet | Tirofiban Hydrochloride supplier | Tirofiban Hydrochloride in vitro | Tirofiban Hydrochloride cell line | Tirofiban Hydrochloride concentration | Tirofiban Hydrochloride nmr