Home Metabolism Phosphorylase inhibitor Tipiracil For research use only.

Tipiracil

Synonyms: TPI (freebase)

Tipiracil [TPI (freebase)] is a potent inhibitor of thymidine phosphorylase. It increases exposure to its co-administered drug by inhibiting its metabolism through thymidine phosphorylase, enhancing its therapeutic effects and is used as adjunct therapy for certain gastric and colorectal cancers.

Tipiracil Chemical Structure

Tipiracil Chemical Structure

CAS No. 183204-74-2

Purity & Quality Control

Batch: E603101 Ethanol]3 mg/mL]false]Water]2 mg/mL]false]DMSO]Insoluble]false Purity: 98.62%
98.62

Tipiracil Related Products

Biological Activity

Description Tipiracil [TPI (freebase)] is a potent inhibitor of thymidine phosphorylase. It increases exposure to its co-administered drug by inhibiting its metabolism through thymidine phosphorylase, enhancing its therapeutic effects and is used as adjunct therapy for certain gastric and colorectal cancers.

Chemical Information & Solubility

Molecular Weight 242.66 Formula

C9H11ClN4O2
CAS No. 183204-74-2 SDF Download Tipiracil SDF
Storage (From the date of receipt)

In vitro
Batch:

Ethanol : 3 mg/mL

Water : 2 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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