Home Ubiquitin E3 ligase Ligand chemical - E3 Ligase chemical Thalidomide-O-COOH (Cereblon ligand 3) For research use only.

Thalidomide-O-COOH (Cereblon ligand 3)

Synonyms: E3 ligase Ligand 3

Thalidomide-O-COOH (Cereblon ligand 3, E3 ligase Ligand 3), a Thalidomide-based Cereblon (CRBN) ligand, is used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs (Proteolysis Targeting Chimera).

Thalidomide-O-COOH (Cereblon ligand 3) Chemical Structure

Thalidomide-O-COOH (Cereblon ligand 3) Chemical Structure

CAS No. 1061605-21-7

Purity & Quality Control

Batch: S679401 DMSO]66 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.87%
99.87

Thalidomide-O-COOH (Cereblon ligand 3) Related Products

Biological Activity

Description Thalidomide-O-COOH (Cereblon ligand 3, E3 ligase Ligand 3), a Thalidomide-based Cereblon (CRBN) ligand, is used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs (Proteolysis Targeting Chimera).
Targets
CRBN [1]

Chemical Information & Solubility

Molecular Weight 332.27 Formula

C15H12N2O7
CAS No. 1061605-21-7 SDF --
Smiles C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 66 mg/mL ( (198.63 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Thalidomide-O-COOH (Cereblon ligand 3) | Thalidomide-O-COOH (Cereblon ligand 3) ic50 | Thalidomide-O-COOH (Cereblon ligand 3) price | Thalidomide-O-COOH (Cereblon ligand 3) cost | Thalidomide-O-COOH (Cereblon ligand 3) solubility dmso | Thalidomide-O-COOH (Cereblon ligand 3) purchase | Thalidomide-O-COOH (Cereblon ligand 3) manufacturer | Thalidomide-O-COOH (Cereblon ligand 3) research buy | Thalidomide-O-COOH (Cereblon ligand 3) order | Thalidomide-O-COOH (Cereblon ligand 3) mouse | Thalidomide-O-COOH (Cereblon ligand 3) chemical structure | Thalidomide-O-COOH (Cereblon ligand 3) mw | Thalidomide-O-COOH (Cereblon ligand 3) molecular weight | Thalidomide-O-COOH (Cereblon ligand 3) datasheet | Thalidomide-O-COOH (Cereblon ligand 3) supplier | Thalidomide-O-COOH (Cereblon ligand 3) in vitro | Thalidomide-O-COOH (Cereblon ligand 3) cell line | Thalidomide-O-COOH (Cereblon ligand 3) concentration | Thalidomide-O-COOH (Cereblon ligand 3) nmr