Home Immunology & Inflammation Galectin inhibitor Olitigaltin (TD-139) For research use only.

Olitigaltin (TD-139)

Synonyms: GB0-139

Olitigaltin (TD-139, GB0-139) is a potent and selective inhibitor of galectin-3 with Kd of 0.036 µM over galectin-1 and galectin-7 with Kd of 2.2 µM and 32 µM, respectively. TD-139 is used potentially for the treatment of idiopathic pulmonary fibrosis (IPF).

Olitigaltin (TD-139) Chemical Structure

Olitigaltin (TD-139) Chemical Structure

CAS No. 1450824-22-2

Purity & Quality Control

Olitigaltin (TD-139) Related Products

Biological Activity

Description Olitigaltin (TD-139, GB0-139) is a potent and selective inhibitor of galectin-3 with Kd of 0.036 µM over galectin-1 and galectin-7 with Kd of 2.2 µM and 32 µM, respectively. TD-139 is used potentially for the treatment of idiopathic pulmonary fibrosis (IPF).
Targets
galectin-3 [1]
(Cell-free assay)		 galectin-1 [1]
(Cell-free assay)		 galectin-7 [1]
(Cell-free assay)
0.036 μM(Kd) 2.2 μM(Kd) 32 μM(Kd)
In vitro
In vitro

In primary lung alveolar epithelial cells (AECs), Olitigaltin (TD-139) which is a novel high-affinity inhibitor of the galectin-3 carbohydrate binding domain, reduces TGF-β1- induced β-catenin translocation to the nucleus, also blocks TGF-β1–induced β-catenin phosphorylation.[2]
In Vivo
In vivo

Olitigaltin (TD-139), a highly potent, selecitve inhibitor of Galectin-3 (Gal-3) carbohydrate, produces a significant decrease in total lung collagen, also decreases β-catenin activation in bleomycin model of pulmonary fibrosis.[2]

Chemical Information & Solubility

Molecular Weight 648.64 Formula

C28H30F2N6O8S
CAS No. 1450824-22-2 SDF --
Smiles C1=CC(=CC(=C1)F)C2=CN(N=N2)C3C(C(OC(C3O)SC4C(C(C(C(O4)CO)O)N5C=C(N=N5)C6=CC(=CC=C6)F)O)CO)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (154.16 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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