Home Cytoskeletal Signaling Kinesin inhibitor Sovilnesib For research use only.

Sovilnesib

Synonyms: AMG 650

AMG 650 (Sovilnesib) is an oral, first in class, selective kinesin-like protein KIF18A inhibitor, can be used for the research of cancer.

Sovilnesib Chemical Structure

Sovilnesib Chemical Structure

CAS No. 2410796-79-9

Purity & Quality Control

Sovilnesib Related Products

Signaling Pathway

Kinesin Signaling Pathways

Kinesin Signaling Pathway

Biological Activity

Description AMG 650 (Sovilnesib) is an oral, first in class, selective kinesin-like protein KIF18A inhibitor, can be used for the research of cancer.
Targets
kinesin-like protein KIF18A [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06084416 Recruiting
High Grade Serous Adenocarcinoma of Ovary|Fallopian Tube Cancer|Primary Peritoneal Carcinoma|Chromosomal Instability
Volastra Therapeutics Inc.
 April 4 2024 Phase 1
NCT04293094 Completed
Advanced Solid Tumors
Volastra Therapeutics Inc.|Amgen
 March 11 2020 Phase 1

Chemical Information & Solubility

Molecular Weight 564.65 Formula

C26H34F2N6O4S
CAS No. 2410796-79-9 SDF --
Smiles CC1=CC(=NC(=N1)N2CCC(F)(F)CC2)NC(=O)C3=C(C=C(N[S;v6](=O)(=O)CCO)C=C3)N4CCC5(CC4)CC5
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (177.1 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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