Home Metabolism LDH inhibitor - CDK inhibitor - Apoptosis related activator - ROS activator Sodium oxamate For research use only.

Sodium oxamate

Synonyms: SO, oxamate sodium, Aminooxoacetic acid sodium salt, Oxamic acid sodium salt

Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.

Sodium oxamate Chemical Structure

Sodium oxamate Chemical Structure

CAS No. 565-73-1

Purity & Quality Control

Sodium oxamate Related Products

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
insect cells Function assay 10 mins Inhibition of human recombinant carboxy-terminal his-tagged LDHB (1 to 333) expressed in insect cells using pyruvate as substrate after 10 mins by UV endpoint analysis, IC50=33.8μM 23628333
Click to View More Cell Line Experimental Data

Biological Activity

Description Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.
Targets
LDHA [1] ROS [2] CDK1 [2]
In vitro
In vitro

Sodium oxamate, a specific inhibitor of LDH-A, enhances the suppressive effects of PARP inhibitors on ovarian cancer without BRCA mutations, remarkably promoting the inhibitory effects of PARP inhibitors on wild-type BRCA ovarian cancer cells.[3]
Cell Research Cell lines wild-type BRCA ovarian cancer cells (A2780 and SKOV3)
Concentrations 50 nM
Incubation Time 24 h
Method

Cell proliferation is evaluated using a Cell Counting Kit-8 (CCK-8). SKOV3 cells and A2780 cells are seeded in a 96-well culture plates at a density of 2×105 cells/well and incubated with different concentrations of the drugs (oxamate, AG14361) for different times. Detection reagent is added to the cells, and the luminescence signals are determined.
In Vivo
In vivo

Sodium oxamate reduces the growth of colorectal cancer in CRC mice, by restoring the down-regulated MMR functional proteins.[4]
Animal Research Animal Models four-week-old male BALB/c nude mice of CRC xenograft
Dosages 500 mg/kg
Administration i.p.
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Chemical Information & Solubility

Molecular Weight 111.03 Formula

C2H2NNaO3
CAS No. 565-73-1 SDF --
Smiles C(=O)(C(=O)[O-])N.[Na+]
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 22 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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