Home Autophagy ULK inhibitor SBP-7455 For research use only.

SBP-7455

SBP-7455 is a dual-Specific ULK1/2 autophagy inhibitor with IC50s of 13 nM and 476 nM for ULK1 and ULK2 in ADP-Glo assay, respectively.

SBP-7455 Chemical Structure

SBP-7455 Chemical Structure

CAS No. 1884222-74-5

Purity & Quality Control

Batch: S339301 DMSO]71 mg/mL]false]Ethanol]71 mg/mL]false]Water]Insoluble]false Purity: 98.61%
98.61

SBP-7455 Related Products

Biological Activity

Description SBP-7455 is a dual-Specific ULK1/2 autophagy inhibitor with IC50s of 13 nM and 476 nM for ULK1 and ULK2 in ADP-Glo assay, respectively.
Targets
ULK1 [1]
(in ADP-Glo assay)		 ULK2 [1]
(in ADP-Glo assay)
13 nM 476 nM

Chemical Information & Solubility

Molecular Weight 354.33 Formula

C16H17F3N4O2
CAS No. 1884222-74-5 SDF --
Smiles COC1=C(OC)C=C(NC2=NC=C(C(=N2)NC3CC3)C(F)(F)F)C=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 71 mg/mL ( (200.37 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 71 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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