Home Neuronal Signaling Neurokinin Receptor antagonist Rolapitant hydrochloride hydrate For research use only.

Rolapitant hydrochloride hydrate

Synonyms: SCH619734 hydrochloride hydrate

Rolapitant hydrochloride hydrate(SCH619734 hydrochloride hydrate) is a long-acting, extremely selective antagonist of the Nk-1 receptor antagonist (NK-1RA) with antiemetic activity. It significantly penetrates the central nervous system (CNS) and used clinically to prevent chemotherapy-induced nausea and vomiting (CINV) in cancer patients undergoing high and moderate emetogenic chemotherapy.

Rolapitant hydrochloride hydrate Chemical Structure

Rolapitant hydrochloride hydrate Chemical Structure

CAS No. 914462-92-3

Purity & Quality Control

Batch: E485301 DMSO]100 mg/mL]false]Ethanol]50 mg/mL]false]Water]Insoluble]false Purity: 99.83%
99.83

Rolapitant hydrochloride hydrate Related Products

Biological Activity

Description Rolapitant hydrochloride hydrate(SCH619734 hydrochloride hydrate) is a long-acting, extremely selective antagonist of the Nk-1 receptor antagonist (NK-1RA) with antiemetic activity. It significantly penetrates the central nervous system (CNS) and used clinically to prevent chemotherapy-induced nausea and vomiting (CINV) in cancer patients undergoing high and moderate emetogenic chemotherapy.

Chemical Information & Solubility

Molecular Weight 554.95 Formula

C25H26F6N2O2.ClH.H2O
CAS No. 914462-92-3 SDF Download Rolapitant hydrochloride hydrate SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (180.19 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 50 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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