Home GPCR & G Protein Ras inhibitor RMC-6291 For research use only.

RMC-6291

RMC-6291 is an orally active and covalent inhibitor of KRASG12C(ON). RMC-6291 forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA).

RMC-6291 Chemical Structure

RMC-6291 Chemical Structure

CAS No. 2641998-63-0

Purity & Quality Control

Batch: E160601 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]Insoluble]false Purity: 99.03%
99.03

RMC-6291 Related Products

Signaling Pathway

Ras Signaling Pathways

Ras Signaling Pathway

Biological Activity

Description RMC-6291 is an orally active and covalent inhibitor of KRASG12C(ON). RMC-6291 forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA).
Targets
KRAS-G12C(ON) [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06128551 Recruiting
Non-Small Cell Lung Cancer (NSCLC)|Colorectal Cancer|Pancreatic Ductal Adenocarcinoma
Revolution Medicines Inc.
 November 14 2023 Phase 1
NCT05462717 Recruiting
Non-Small Cell Lung Cancer (NSCLC)|Colorectal Cancer (CRC)|Pancreatic Ductal Adenocarcinoma|Advanced Solid Tumor
Revolution Medicines Inc.
 September 19 2022 Phase 1

Chemical Information & Solubility

Molecular Weight 1012.26 Formula

C55H78FN9O8
CAS No. 2641998-63-0 SDF Download RMC-6291 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (98.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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