Home Microbiology Reverse Transcriptase inhibitor Rilpivirine Hydrochloride For research use only.

Rilpivirine Hydrochloride

Synonyms: TMC278

Rilpivirine (TMC278), is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz.

Rilpivirine Hydrochloride Chemical Structure

Rilpivirine Hydrochloride Chemical Structure

CAS No. 700361-47-3

Purity & Quality Control

Batch: E081501 DMSO]81 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.91%
99.91

Rilpivirine Hydrochloride Related Products

Signaling Pathway

Reverse Transcriptase Signaling Pathways

Reverse Transcriptase Signaling Pathway

Biological Activity

Description Rilpivirine (TMC278), is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz.
Targets
NNRT [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01804244 Completed
Healthy
Janssen Pharmaceutical K.K.
 March 2013 Phase 4
NCT01656018 Completed
Healthy
Janssen Research & Development LLC
 November 2012 Phase 1
NCT01519128 Completed
Healthy
Janssen R&D Ireland
 January 2012 Phase 1
NCT01288755 Completed
HIV Infections
Tibotec Pharmaceuticals Ireland|Raltegravir is provided by Merck.
 February 2011 Phase 1

Chemical Information & Solubility

Molecular Weight 402.88 Formula

C22H18N6.ClH
CAS No. 700361-47-3 SDF --
Smiles Cl.CC1=C(NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C(=CC(=C1)\C=C\C#N)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 81 mg/mL ( (201.05 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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