Home Neuronal Signaling Histamine Receptor antagonist Ranitidine Hydrochloride For research use only.

Ranitidine Hydrochloride

Synonyms: AH19065

Ranitidine (AH19065) is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.

Ranitidine Hydrochloride Chemical Structure

Ranitidine Hydrochloride Chemical Structure

CAS No. 66357-59-3

Purity & Quality Control

Batch: S180101 DMSO]70 mg/mL]false]Water]70 mg/mL]false]Ethanol]Insoluble]false Purity: 100%
100

Ranitidine Hydrochloride Related Products

Signaling Pathway

Histamine Receptor Signaling Pathways

Histamine Receptor Signaling Pathway

Biological Activity

Description Ranitidine (AH19065) is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.
Targets
Histamine H2 receptor [1]
In vitro
In vitro Ranitidine sensitizes hepatocytes to killing by cytotoxic products from activated neutrophils, whereas Famotidine lacks this ability. [1] Ranitidine inhibits the production of tumor necrosis factor-alpha (TNF-alpha) in monocytes stimulated with lipopolysaccharide in vitro. [2] Ranitidine reduces the Kel of morphine dose-dependently with a maximum effect of 50%, and increases the relative concentration of morphine-6-glucuronide to morphine-3-glucuronide in isolated guinea pig hepatocytes. Ranitidine gradually decreases the morphine-3-glucuronide/morphine-6-glucuronide ratio by up to 21%. [3]
In Vivo
In vivo Ranitidine results in liver injury as evidence by increased in serum alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities within 6 hours after Ranitidine administration in rats. [1] Ranitidine inhibits hepatic ischemia/reperfusion-induced increase in hepatic tissue levels of TNF-alpha, cytokine-induced neutrophil chemoattractant, and hepatic accumulation of neutrophils in rats. [2] Ranitidine cotreatment enhances LPS-induced coagulation prior to liver injury, and anticoagulants reduce liver damage in LPS/RAN-treated rats. Ranitidine /LPS-treated rats results in the formation of fibrin clots in liver sinusoids, and prevention of fibrin deposition associated with reduced hepatocellular injury. Ranitidine cotreatment enhances the LPS-induced TNF increase before the onset of hepatocellular injury in rats. [4] Ranitidine displays anxiolytic effects in the elevated plus-maze as indicated by an increase in time spent in the open arms, more open-arm scanning and more end-excursions in rats. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05399927 Completed
Music Therapy|Cardiovascular Diseases|Critical Care|Emergencies
Universidad Miguel Hernandez de Elche
 July 2015 Not Applicable
NCT01539655 Completed
Medullary Thyroid Cancer
Sanofi
 February 2012 Phase 1
NCT01017198 Completed
Advanced Solid Tumors
Biogen
 November 2009 Phase 1

Chemical Information & Solubility

Molecular Weight 350.86 Formula

C13H22N4O3S.HCl
CAS No. 66357-59-3 SDF Download Ranitidine Hydrochloride SDF
Smiles CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 70 mg/mL ( (199.5 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 70 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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