Home Transmembrane Transporters Proton Pump inhibitor Rabeprazole sodium For research use only.

Rabeprazole sodium

Synonyms: Aciphex Sodium, Dexrabeprazole Sodium, Habeprazole Sodium

Rabeprazole (Aciphex, Dexrabeprazole, Habeprazole) is an antiulcer drug in the class of proton pump inhibitors.

Rabeprazole sodium Chemical Structure

Rabeprazole sodium Chemical Structure

CAS No. 117976-90-6

Purity & Quality Control

Rabeprazole sodium Related Products

Signaling Pathway

Proton Pump Signaling Pathways

Proton Pump Signaling Pathway

Biological Activity

Description Rabeprazole (Aciphex, Dexrabeprazole, Habeprazole) is an antiulcer drug in the class of proton pump inhibitors.
Targets
proton pump [1]
In vitro
In vitro Administration of rabeprazole leads to a marked decrease in the viability of MKN-28 cells. Exposure to rabeprazole induces significant apoptosis in AGS cells. Rabeprazole completely inhibits the phosphorylation of ERK 1/2 in the MKN-28 cells, whereas the same effect is not observed in either the KATO III or MKN-45 cells. Rabeprazole is able to efficaciously inhibit the phosphorylation of ERK 1/2 in the gastric cancer cells.Thus, rabeprazole can attenuate the cell viability of human gastric cancer cells through inactivation of the ERK1/2 signaling pathway[2].
Cell Research Cell lines Human gastric cancer cell lines, KATO III, MKN-28 and MKN-45
Concentrations 0.2 mM
Incubation Time 16 h
Method Rabeprazole is administrated to three gastric cancer cell lines, KATO III, MKN-28 and MKN-45, at a dosage of 0.2 mM for 16 h. The viability of these cells is determined by a trypan blue exclusion assay.
In Vivo
In vivo Rabeprazole does not appear to exacerbate bone metabolic disorders in gastrectomized rats, but rather ameliorates the TG-induced BMD decrease[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01101646 Completed
Gastroesophageal Reflux
Johnson & Johnson Pharmaceutical Research & Development L.L.C.
 August 2008 Phase 1

Chemical Information & Solubility

Molecular Weight 381.42 Formula

C18H20N3O3S.Na
CAS No. 117976-90-6 SDF Download Rabeprazole sodium SDF
Smiles CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3[N-]2)OCCCOC.[Na+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 76 mg/mL ( (199.25 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 76 mg/mL

Ethanol : 76 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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