Home Neuronal Signaling Histamine Receptor antagonist Promethazine For research use only.

Promethazine

Promethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties.

Promethazine Chemical Structure

Promethazine Chemical Structure

CAS No. 60-87-7

Purity & Quality Control

Batch: S519601 DMSO]29 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.61%
99.61

Promethazine Related Products

Signaling Pathway

Histamine Receptor Signaling Pathways

Histamine Receptor Signaling Pathway

Biological Activity

Description Promethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties.
Targets
histamine H1 receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05759481 Recruiting
Post-operative Nausea and Vomiting
Milton S. Hershey Medical Center
 February 1 2024 Phase 2
NCT04805073 Recruiting
Pruritus|Pregnancy Related
University of Florida
 August 9 2021 Phase 4
NCT03539562 Completed
Labor Pain|Early Labor
University of California San Francisco
 September 27 2017 --
NCT02465866 Completed
Healthy
Charleston Laboratories Inc
 November 2014 Phase 1
NCT01644838 Completed
Labor Pain
Mashhad University of Medical Sciences
 August 2010 Phase 2|Phase 3

Chemical Information & Solubility

Molecular Weight 284.42 Formula

C17H20N2S
CAS No. 60-87-7 SDF --
Smiles CC(CN1C2=CC=CC=C2SC3=CC=CC=C13)N(C)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 29 mg/mL ( (101.96 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Promethazine | Promethazine supplier | purchase Promethazine | Promethazine cost | Promethazine manufacturer | order Promethazine | Promethazine distributor