Home Biosimilar Antibodies Endocrinology & Hormones GPR Petosemtamab (Anti-EGFR / LGR5)
For research use only. Not for use in humans.

Petosemtamab (Anti-EGFR / LGR5)

Synonyms:  MCLA 158

Petosemtamab (Anti-EGFR/LGR5) is a highly potent bispecific antibody against EGFR (Kd 0.22 nM) and LGR5 (Kd 0.86 nM). It blocks the appearance of metastases and slows the growth of primary tumors in experimental cancer models. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC). MW: 145.5 KD.

Petosemtamab (Anti-EGFR / LGR5)

Quality Control

Batch: A247401 Purity: 99% Protein concentration: 5.241mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

Name Citation GPR Others
AZD1981 2
NF-56-EJ40 0
ML401 0
PH-064 0
NE 52-QQ57 1 IL-1β,TNF-α,PGE2
NIBR189 0
JMS-17-2 3
OC000459 0
Kisspeptin-10 (human) 0
CLP-3094 0 AR
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Petosemtamab (Anti-EGFR/LGR5) is a highly potent bispecific antibody against EGFR (Kd 0.22 nM) and LGR5 (Kd 0.86 nM). It blocks the appearance of metastases and slows the growth of primary tumors in experimental cancer models. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC). MW: 145.5 KD.

Product Details

CAS No. 2213450-26-9
Molecular Weight 145.5 kDa
Isotype Human IgG1
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Tech Support

Handling Instructions

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