Home Neuronal Signaling Histamine Receptor antagonist Pemirolast potassium For research use only.

Pemirolast potassium

Synonyms: BMY26517

Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

Pemirolast potassium Chemical Structure

Pemirolast potassium Chemical Structure

CAS No. 100299-08-9

Purity & Quality Control

Batch: S400801 Water]53 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.97%
99.97

Pemirolast potassium Related Products

Signaling Pathway

Histamine Receptor Signaling Pathways

Histamine Receptor Signaling Pathway

Biological Activity

Description Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.
Targets
Histamine H1 receptor [2]
In vitro
In vitro Pemirolast potassium (BMY 26517) is a new oral, nonbronchodilator antiallergy medication that is being evaluated for the therapy of asthma. [1] Pemirolast potassium (BMY 26517) inhibits chemical mediator release from tissue mast cells and is also shown to inhibit the release of peptides including substance P, [2] neurokinin (NK) A, and calcitonin gene-related peptide (CGRP) from sensory nerves. [3] Pemirolast potassium is used for the treatment of allergic conjunctivitis and prophylaxis for pulmonary hypersensitivity reactions to drugs such as paclitaxel. [4]
In Vivo
In vivo Pemirolast potassium (BMY 26517) reduces kaolin intake by inhibition of substance P release in rats. [2] Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats. [3]

Chemical Information & Solubility

Molecular Weight 266.3 Formula

C10H7N6O.K
CAS No. 100299-08-9 SDF Download Pemirolast potassium SDF
Smiles CC1=CC=CN2C1=NC=C(C2=O)C3=NN=N[N-]3.[K+]
Storage (From the date of receipt)

In vitro
Batch:

Water : 53 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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