Home Endocrinology & Hormones SSTR agonist Paltusotine For research use only.

Paltusotine

Synonyms: CRN00808

Paltusotine (CRN00808) is an orally active, nonpeptide selective somatostatin type 2 (SST2) receptor agonist, has the potential for maintaining GH and IGF-1 levels after depot somatostatin receptor ligand therapy.

Paltusotine Chemical Structure

Paltusotine Chemical Structure

CAS No. 2172870-89-0

Purity & Quality Control

Batch: E240601 DMSO]91 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.92%
99.92

Paltusotine Related Products

Biological Activity

Description Paltusotine (CRN00808) is an orally active, nonpeptide selective somatostatin type 2 (SST2) receptor agonist, has the potential for maintaining GH and IGF-1 levels after depot somatostatin receptor ligand therapy.
Targets
SST2 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04246749 Completed
Healthy Volunteers
Crinetics Pharmaceuticals Inc.
 September 17 2019 Phase 1

Chemical Information & Solubility

Molecular Weight 456.49 Formula

C27H22F2N4O
CAS No. 2172870-89-0 SDF --
Smiles NC1CCN(CC1)C2=C(C=NC3=C2C=C(C=C3)C4=C(O)C(=CC=C4)C#N)C5=CC(=CC(=C5)F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 91 mg/mL ( (199.34 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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