Home GPCR & G Protein Glucagon Receptor agonist Orforglipron For research use only.

Orforglipron

Synonyms: LY3502970

Orforglipron(LY3502970) is a non-peptidal agonist of glucagon-like peptide 1(GLP-1) receptor. It can be used efficiently in glycemic control and weight reduction in type 2 diabetes mellitus (T2DM), obesity or both.

Orforglipron Chemical Structure

Orforglipron Chemical Structure

CAS No. 2212020-52-3

Purity & Quality Control

Batch: S985201 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.00%
99.00

Orforglipron Related Products

Biological Activity

Description Orforglipron(LY3502970) is a non-peptidal agonist of glucagon-like peptide 1(GLP-1) receptor. It can be used efficiently in glycemic control and weight reduction in type 2 diabetes mellitus (T2DM), obesity or both.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06370728 Not yet recruiting
Healthy
Eli Lilly and Company
 May 3 2024 Phase 1
NCT06109311 Recruiting
Type 2 Diabetes
Eli Lilly and Company
 November 10 2023 Phase 3
NCT06085482 Completed
Healthy
Eli Lilly and Company
 October 19 2023 Phase 1
NCT06023095 Active not recruiting
Overweight|Obesity
Eli Lilly and Company
 September 21 2023 Phase 1
NCT05936138 Completed
Renal Insufficiency|Healthy
Eli Lilly and Company
 July 13 2023 Phase 1

Chemical Information & Solubility

Molecular Weight 882.96 Formula

C48H48F2N10O5
CAS No. 2212020-52-3 SDF Download Orforglipron SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (113.25 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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