Onartuzumab (Anti-HGFR / c-Met)

Synonyms: MetMAb

Catalog No.A2468 Purity:99%

Onartuzumab (Anti-HGFR / c-Met) is a unique, humanized and affinity-matured monovalent (one-armed) monoclonal antibody against the MET receptor. Onartuzumab potently inhibits HGF binding and receptor phosphorylation and signaling. Onartuzumab has antibody-like pharmacokinetics and antitumor activity. MW: 144.64 KD.

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Purity & Quality Control

Batch: A246801 Purity: 99% Protein concentration: 5.76mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective c-Met Inhibitors

Name	Citation	c-Met	Others
Foretinib	93	++++	KDR,Tie-2,VEGFR3/FLT4
PHA-665752	91	++	RON,Flk1
SU11274	63	+
SGX-523	133	+++
BMS-777607	56	+++	Axl,RON,Tyro3
Tivantinib	48	+
JNJ-38877605	52	+++
PF-04217903	22	++
MGCD-265 analog	12	++++	RON,VEGFR2,VEGFR1
BMS-754807	51	++	Insulin Receptor,IGF-1R,TrkB
BMS-794833	1	+++	VEGFR2
AMG-208	0	++
MK-2461	4	++++	c-Met (Y1235D),c-Met (Y1230C),c-Met (N1100)
Golvatinib (E7050)	8	+	VEGFR2
AMG-458	0	++++
Tepotinib	18	+++
NVP-BVU972	1	+
Savolitinib (AZD6094)	16	++	p-Met
S49076	1	++++	Mer,Axl,FGFR3
Merestinib (LY2801653)	9	+++
AMG 337	2	++++
NPS-1034	3	+	Axl

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Onartuzumab (Anti-HGFR / c-Met) is a unique, humanized and affinity-matured monovalent (one-armed) monoclonal antibody against the MET receptor. Onartuzumab potently inhibits HGF binding and receptor phosphorylation and signaling. Onartuzumab has antibody-like pharmacokinetics and antitumor activity. MW: 144.64 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1133766-06-9
Molecular Weight	144.64 kDa
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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