Home Transmembrane Transporters Proton Pump inhibitor - ATPase inhibitor Esomeprazole magnesium For research use only.

Esomeprazole magnesium

Synonyms: NEXIUM

Esomeprazole Magnesium(NEXIUM) is a proton pump inhibitor to reduce gastric acid secretion through inhibition of H(+)/K(+)-ATPase in gastric parietal cells.

Esomeprazole magnesium Chemical Structure

Esomeprazole magnesium Chemical Structure

CAS No. 161973-10-0

Purity & Quality Control

Esomeprazole magnesium Related Products

Signaling Pathway

Proton Pump Signaling Pathways

Proton Pump Signaling Pathway

Biological Activity

Description Esomeprazole Magnesium(NEXIUM) is a proton pump inhibitor to reduce gastric acid secretion through inhibition of H(+)/K(+)-ATPase in gastric parietal cells.
Targets
H(+)/K(+)-ATPase [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02477475 Completed
Reflux Esophagitis
AstraZeneca
 July 7 2015 --
NCT02277886 Unknown status
Gastroesophageal Reflux Disease|Heartburn|Sleep Disturbance
Chang Gung Memorial Hospital|TTY Biopharm
 November 2014 Phase 4
NCT01130935 Completed
Gastric Acid Suppression|Proton Pump Inhibitors
AstraZeneca
 May 2010 --
NCT01135472 Completed
Healthy
City of Hope Medical Center
 March 2010 Phase 1
NCT00332748 Terminated
Cancer
Bristol-Myers Squibb
 December 2006 Phase 1

Chemical Information & Solubility

Molecular Weight 713.12 Formula

C34H36MgN6O6S2
CAS No. 161973-10-0 SDF Download Esomeprazole magnesium SDF
Smiles CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Mg+2]
Storage (From the date of receipt)

In vitro
Batch:


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Esomeprazole magnesium | Esomeprazole magnesium supplier | purchase Esomeprazole magnesium | Esomeprazole magnesium cost | Esomeprazole magnesium manufacturer | order Esomeprazole magnesium | Esomeprazole magnesium distributor