Home Neuronal Signaling Beta Amyloid chemical (-)-epigallocatechin For research use only.

(-)-epigallocatechin

(-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.

(-)-epigallocatechin Chemical Structure

(-)-epigallocatechin Chemical Structure

CAS No. 970-74-1

Purity & Quality Control

Batch: S392201 DMSO]61 mg/mL]false]]]false]]]false Purity: 99.38%
99.38

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Signaling Pathway

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Biological Activity

Description (-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.
In vitro
In vitro (-)-Epigallocatechin (EGC) shows the anti-proliferation effects on AML cells. EGC-treated cells show not only the suppression of FLT3, but also the suppression of phosphorylation of MAPK, AKT and STAT5. EGC suppresses FLT3 expression through Hsp90[1]. EGC inhibits heregulin-β1 (HRG)-induced migration/invasion of MCF-7 human breast carcinoma cells. It does not cause modification of MCF-7 cell cycle phases. EGC inhibits HRG-induced phosphorylation of ErbB2/ErbB3 at a low cell confluence and does not activate Akt at either a low or high cell confluence[2].
Cell Research Cell lines MOLM-13, MOLM-14, MV4-11 and KOCL-48 cells
Concentrations 0-200 μM
Incubation Time 72 h
Method Cell proliferation is determined by trypan blue dye exclusion test. Briefly, cells are seeded in 6-well plates at a density of 1×105 cells/ml in the presence of different concentrations of EGCG, EGC, ECG and C for 72 hours. After the treatment, 10 µl of the cell suspension is mixed with 10 µl of 0.4% trypan blue, and alive cells are counted manually using a hemacytometer.

Chemical Information & Solubility

Molecular Weight 306.27 Formula

C15H14O7
CAS No. 970-74-1 SDF --
Smiles C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 61 mg/mL ( (199.17 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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