Home Epigenetics PRMT inhibitor MS023 hydrochloride For research use only.

MS023 hydrochloride

Synonyms: Compound 3

MS023 hydrochloride(Compound 3) is a potent, selective and cell-active inhibitor of human type I protein arginine methyltransferases (PRMT), with IC50 values of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively.

MS023 hydrochloride Chemical Structure

MS023 hydrochloride Chemical Structure

CAS No. 2108631-19-0

Purity & Quality Control

Batch: E288701 DMSO]57 mg/mL]false]Ethanol]57 mg/mL]false]Water]Insoluble]false Purity: 99.56%
99.56

MS023 hydrochloride Related Products

Biological Activity

Description MS023 hydrochloride(Compound 3) is a potent, selective and cell-active inhibitor of human type I protein arginine methyltransferases (PRMT), with IC50 values of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively.
Targets
PRMT6 [1] PRMT8 [1] PRMT1 [1] PRMT4 [1] PRMT3 [1]
4 nM 5 nM 30 nM 83 nM 119 nM

Chemical Information & Solubility

Molecular Weight 396.78 Formula

C17H25N3O.3ClH
CAS No. 2108631-19-0 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 57 mg/mL ( (143.65 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 57 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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