Home Endocrinology & Hormones Glucocorticoid Receptor agonist Mometasone furoate For research use only.

Mometasone furoate

Synonyms: SCH-32088,mometasone 17-furoate

Mometasone Furoate (SCH-32088,mometasone 17-furoate) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.

Mometasone furoate Chemical Structure

Mometasone furoate Chemical Structure

CAS No. 83919-23-7

Purity & Quality Control

Mometasone furoate Related Products

Biological Activity

Description Mometasone Furoate (SCH-32088,mometasone 17-furoate) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
Targets
Glucocorticoid receptor [1]
In vitro
In vitro

Mometasone furoate efficiently suppresses production of cytokines including interleukin (IL)-4, IL-5, and interferon-gamma in anti-CD3-stimulated human CD4+ T cells. Mometasone furoate effectively inhibits the activation of Th cells including type 2 Th (Th2) in the draining LN, thus leading to the suppression of the IgE response. [1]
In Vivo
In vivo

Mometasone causes a decrease in the instances of nasal rubbing and an inhibition of this response is observed during the treatment period in rats. [2] Mometasone (3 mg/kg) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested in mice. Mometasone, given an hour after the last allergen challenge, dose-dependently inhibits the allergen-induced increase in Penh with about a 10-fold loss of potency when compared with the pre-challenge treatment schedule. [3] Mometasone furoate (0.02%) and fluticasone propionate (0.1%) significantly inhibits the increase of antigen-induced nasal rubbing even 6 hours after topical application, indicating that both drugs have a long-lasting effect. [4] Mometasone furoate dose-dependently inhibits the elevated eosinophil numbers in the bronchoalveolar lavage fluid and lung tissues of sensitized, ovalbumin challenged mice. Mometasone furoate (33 mg/kg) reduces the percentage of CD44+ T-helper cells (activated/memory cells) to the levels observed in non-sensitized, ovalbumin-challenged mice. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02967731 Completed
Chronic Sinusitis
Lyra Therapeutics
 June 6 2017 Phase 1
NCT01894503 Completed
Chronic Sinusitis
Intersect ENT
 June 2013 Phase 2
NCT01702103 Unknown status
Nasal Obstruction|Sneezing|Itching
PH&T S.p.A.
 October 2012 Phase 3

Chemical Information & Solubility

Molecular Weight 521.43 Formula

C27H30Cl2O6
CAS No. 83919-23-7 SDF Download Mometasone furoate SDF
Smiles CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CCl)OC(=O)C5=CC=CO5)C)O)Cl)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 25 mg/mL ( (47.94 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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