Home Proteases MALT inhibitor Mepazine hydrochloride For research use only.

Mepazine hydrochloride

Synonyms: Pecazine hydrochloride

Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective inhibitor of MALT1 protease, with IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 aa 325-760. It effectively suppresses the activation of the NF-kB pathway specifically in activated B cell subtype of diffuse large B cell lymphoma (ABC-DLBCL) cells and makes it a promising candidate for the treatment of ABC-DLBCL.

Mepazine hydrochloride Chemical Structure

Mepazine hydrochloride Chemical Structure

CAS No. 2975-36-2

Purity & Quality Control

Batch: E174001 DMSO]69 mg/mL]false]Ethanol]69 mg/mL]false]Water]2 mg/mL]false Purity: 99.58%
99.58

Mepazine hydrochloride Related Products

Biological Activity

Description Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective inhibitor of MALT1 protease, with IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 aa 325-760. It effectively suppresses the activation of the NF-kB pathway specifically in activated B cell subtype of diffuse large B cell lymphoma (ABC-DLBCL) cells and makes it a promising candidate for the treatment of ABC-DLBCL.

Chemical Information & Solubility

Molecular Weight 346.92 Formula

C19H22N2S.ClH
CAS No. 2975-36-2 SDF Download Mepazine hydrochloride SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 69 mg/mL ( (198.89 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 69 mg/mL

Water : 2 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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